alpha-Trifluoromethyl-beta-aryl enamines in the synthesis of trifluoromethylated heterocycles by the Fischer and the Pictet-Spengler reactionsстатья
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Аннотация:alpha-Trifluoromethyl-beta-aryl enamines were successfully used as synthetic equivalents of benzyltri-fluoromethyl ketones in both the Fischer indole synthesis and the Pictet-Spengler reaction. Accordingly, 2-trifluoromethyl indoles and a variety of trifluoromethylated 4,5,6,7-terahydro-1H-pyridines including carbolines were synthesized in moderate to good yields. (C) 2009 Elsevier Ltd. All rights reserved.