Rabbit Models of Ocular Diseases: New Relevance for Classical Approaches

Zernii, E.Y.; Baksheeva, V.E.; Iomdina, E.N.; Averina, O.A.; Permyakov, S.E.; Philippov, P.P.; Zamyatnin, A.A.; Senin, I.I.

Авторы: Zernii Evgeni Y., Baksheeva Viktoriia E., Iomdina Elena N., Averina Olga A., Permyakov Sergei E., Philippov Pavel P., Zamyatnin Andrey A., Senin Ivan I.
Журнал: CNS and Neurological Disorders - Drug Targets
Том: 15
Номер: 3
Год издания: 2016
Издательство: Bentham Science Publishers
Местоположение издательства: Netherlands
Первая страница: 267
Последняя страница: 91
DOI: 10.2174/1871527315666151110124957
Аннотация: Over 100 million individuals are affected by irreversible visual impairments and blindness worldwide, while ocular diseases remain a challenging problem despite significant advances in modern ophthalmology. Development of novel drugs and drug delivery mechanisms, as well as advanced ophthalmological techniques requires experimental models including animals, capable of developing ocular diseases with similar etiology and pathology, suitable for future trials of new therapeutic approaches. Although experimental ophthalmology and visual research are traditionally performed on rodent models, these animals are often unsuitable for pre-clinical drug efficacy and safety studies, as well as for testing novel drug delivery approaches, e.g. controlled release of pharmaceuticals using intra-ocular implants. Therefore, rabbit models of ocular diseases are particularly useful in this context, since rabbits can be easily handled, while sharing more common anatomical and biochemical features with humans compared to rodents, including longer life span and larger eye size. This review provides a brief description of clinical, morphological and mechanistic aspects of the most common ocular diseases (dry eye syndrome, glaucoma, age-related macular degeneration, light-induced retinopathies, cataract and uveitis) and summarizes the diversity of current strategies for their experimental modeling in rabbits. Several applications of some of these models in ocular pharmacology and eye care strategies are also discussed.
Добавил в систему: Зерний Евгений Юрьевич

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Rabbit Models of Ocular Diseases: New Relevance for Classical Approachesстатья

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