Complexes of star-shaped cationic polyelectrolytes with anionic liposomes: towards multi-liposomal assemblies with controllable stabilityстатья
Статья опубликована в высокорейтинговом журнале
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Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 9 июня 2016 г.
Аннотация:Complexes were formed via the electrostatic interaction between 30 and 50-nm anionic liposomes and a star-shaped polyelectrolyte, poly{[2-(methacryloyloxy)ethyl]trimethyl ammonium iodide}, having cationic arms that radiate from a silicon-based central core. The complexation was investigated with attention given to assessing the capacity of the cationic stars for the anionic liposomes (both liquid and solid); the integrity of the complexed liposomes; and the stability of the resulting star/liposome complexes in aqueous salt solutions. We have found that by changing the content of anionic groups in the liposomal membrane as well as the phase-state of membrane, the stability of star/liposome complexes in aqueous salt media can be controlled. The liquid liposomes with 0.1 mol fraction of anionic palmitoyloleoylphosphatidylserine (POPS1−), and solid liposomes with 0.1 mol fraction of POPS1−, retain their integrity when bound to the stars, with the resulting star/liposome complexes being stable in a physiological solutions, e.g. [NaCl] = 0.15 M. Multi-liposomal complexes containing up to 10 liposomes per star seem to hold promise as carriers for biologically active compounds.