|
ИСТИНА |
Войти в систему Регистрация |
ИПМех РАН |
||
Characterization at the individual cell level and in whole blood samples of shear stress preventing red blood cells aggregationстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 9 июня 2016 г.
- Авторы: Lee K., Kinnunen M., Danilina A.V., Ustinov V.D., Shin S., Meglinski I., Priezzhev A.V.
- Журнал: Journal of Biomechanics
- Том: 49
- Номер: 7
- Год издания: 2016
- Издательство: Elsevier BV
- Местоположение издательства: Netherlands
- Первая страница: 1021
- Последняя страница: 1026
- DOI: 10.1016/j.jbiomech.2016.02.011
- Аннотация: The aggregation of red blood cells (RBC) is an intrinsic feature of blood that has a strong impact on its microcirculation. For a number of years it has been attracting a great attention in basic research and clinical studies. Here, we study a relationship between the RBC aggregation parameters measured at the individual cell level and in a whole blood sample. The home made optical tweezers were used to measure the aggregating and disaggregating forces for a pair of interacting RBCs, at the individual cell level, in order to evaluate the corresponding shear stresses. The RheoScan aggregometer was used for the measurements of critical shear stress (CSS) in whole blood samples. The correlation between CSS and the shear stress required to stop an RBC pair from aggregating was found. The shear stress required to disaggregate a pair of RBCs using the double channel optical tweezers appeared to be about 10 times higher than CSS. The correlation between shear stresses required to prevent RBCs from aggregation at the individual cell level and in whole blood samples was estimated and assessed quantitatively. The experimental approach developed has a high potential for advancing hemorheological studies.
- Добавил в систему: Приезжев Александр Васильевич