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Small-angle neutron and X-ray scattering analysis of the supramolecular organization of rhodopsin in photoreceptor membraneстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 20 декабря 2019 г.
- Авторы: Feldman Tatiana B., Ivankov Oleksandr I., Kuklin Alexander I., Murugova Tatiana N., Yakovleva Marina A., Smitienko Olga A., Kolchugina Irina B., Adam Round, Gordeliy Valentin I., Belushkin Alexander V., Ostrovsky Mikhail A.
- Журнал: Biochimica et Biophysica Acta - Biomembranes
- Том: 1861
- Номер: 10
- Год издания: 2019
- Издательство: Elsevier BV
- Местоположение издательства: Netherlands
- Первая страница: 183000
- DOI: 10.1016/j.bbamem.2019.05.022
- Аннотация: The supramolecular organization of the visual pigment rhodopsin in the photoreceptor membrane remains contentious. Specifically, whether this G protein-coupled receptor functions as a monomer or dimer remains unknown, as does the presence or absence of ordered packing of rhodopsin molecules in the photoreceptor membrane. Completely opposite opinions have been expressed on both issues. Herein, using small-angle neutron and X-ray scattering approaches, we performed a comparative analysis of the structural characteristics of the photoreceptor membrane samples in buffer, both in the outer segment of photoreceptor cells, and in the free photoreceptor disks. The average distance between the centers of two neighboring rhodopsin molecules was found to be ~5.8 nm in both cases. The results indicate an unusually high packing density of rhodopsin molecules in the photoreceptor membrane, but molecules appear to be randomly distributed in the membrane without any regular ordering.
- Добавил в систему: Фельдман Татьяна Борисовна