Bone health in young women with central hypogonadism is similar or worse than in healthy postmenopausal womenстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 19 июня 2019 г.
Аннотация:Decreased estrogen level in perimenopausal age is associated with the increased bone mineral density (BMD) loss and is a pathogenic base of osteoporosis in the age group of women. However, BMD loss can occur not only in the postmenopausal period but also in different hypoestrogenic conditions in younger women.
The study aim was to estimate markers of mineral turnover and BMD in young women with the central hypogonadism and to compare them with healthy young women of similar age, and also with healthy postmenopausal women of middle/advanced age.
One hundred seventy women were examined: 73 patients with the central hypogonadism (CH) isolated hypogonadism n=35, hypopituitarism n=38, age 25 [21.2; 30.5] y.o., amenorrhea duration 5.2 [2.3; 10.1] years; 47 healthy women with regular menstrual cycles (HW), age 24 [23.1; 28] y.o. (p=0.93 in comparison with women with CH) and 50 healthy postmenopausal women, age 56 [53; 58] y.o., postmenopause duration 6 [2.1; 10] years (p=0.9 in comparison with CH).
In CH concentrations of Ca++ and alkaline phosphatase as well as serum collagen type 1 cross-linked C-telopeptide were significantly higher than in HW of similar age however, didn't differ from those in HPm. BMD was significantly lower in both skeleton sites in CH in comparison with HPm (T-criteria ≤-2.5SD in lumbar vertebras 55% and 28% respectively р<0.001, in a hip 27% and 7% respectively p=0.002). The factors promoting lower BMD in CH were the amenorrhea duration, low levels of the total testosterone, and primary amenorrhea. Distinctions of mineral turnover markers and BMD in isolated hypogonadism and hypopituitarism was not revealed.
Thus, metabolic parameters of bone health in young women with central hypogonadism is similar to those in postmenopause and BMD is even lower than in postmenopause at the corresponding middle age.