Levetiracetam modifies the pattern of audiogenic locomotive response in wistar and krushinsky - Molodkina strain ratsстатья
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Дата последнего поиска статьи во внешних источниках: 4 февраля 2014 г.
Аннотация:The novel antiepileptic drug levetiracetam (keppra, 80 mg/kg, i. p.) produces a pronounced anticonvulsant effect on all parameters of the audiogenic locomotion response in Wistar rats, leading to the prevention of acoustic seizures approximately in 50% animals. Keppra injection also led to a decrease in the intensity of single audiogenic convulsive episode, a twofold prolongation of the latency of motor reaction, and a change in the pattern of seizure reaction toward increasing number of rats with "one-wave" response. In contrast, a lack of sound resistant animals and the change from one- to two-wave audiogenic response were observed in Krushinsky - Molodkina strain rats.