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Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
Аннотация:In 1924 Hilde Mangold and Hans Spemann revealed by transplantation of the dorsal blastopore
lip of an amphibian embryo to a host embryo’s ventral side that it can act as an organiser to induce a secondary body axis [1]. The "organiser" experiment has fueled research in vertebrate developmental biology until today [2,3]. While an organiser might have been present in the chordate ancestor [4], it is not clear, how widespread the principle of the blastoporal organiser is and what are its evolutionary roots. Here, we examined the organising activity of embryos of the sea anemone Nematostella vectensis, a representative of a basal animal phylum, which has retained many ancestral traits. We show by transplantation of small parts of the gastrula embryo, that the blastopore lip, but not tissue from other parts of the embryo, is able to act as an organiser and to induce the formation of a secondary body axis with high efficiency. These results strongly suggest that the principle of a blastoporal organiser predates the divergence of Cnidaria and Bilateria, at least 550 Mio years ago.