Distinguishing between tumor, infiltrated and normal cortex regions in glioma patients with Raman spectroscopyстатьяТезисы
Статья опубликована в высокорейтинговом журнале
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Дата последнего поиска статьи во внешних источниках: 24 января 2020 г.
Аннотация:Here we describe application of Raman microspectroscopy to the distinguishing between normal, infiltrating (peritumoral) and tumoral regions in patients with glioma of II and IV grades. We demonstrate that Raman spectroscopy with laser excitations at 633 and 532 nm allows to discriminatebetween normal cortex and tumor (dense cancer, grade 2-4 glioma) and to visualize the infiltration of gliomacells in the peritumoral region. The study wasapproved by the Ethical Committee of the Privolzhskiy Research Medical University, and informed consent wasobtained from all patients. Raman spectra of brain slices contain set of peaks corresponding to proteins, lipids and cytochromes in mitochondria. Raman images of peritumoral regions provide clearvisualization of cancer cells infiltrated these brain parts. We suggest that the cooperative analysis of RS peaks corresponding to the relative amount of proteins and redox state of mitochondria can help to distinguish infiltrated peritumoral regions from the healthy brain tissue.