COMMON VARIATION IN PHACTR1 IS ASSOCIATED WITH SUSCEPTIBILITY TO CERVICAL ARTERY DISSECTION

Stéphanie, D.; Kamatani, Y.; M, M.T.; Kloss, M.; Chauhan, G.; T, E.S.; Pezzini, A.; Thijs, V.; S, M.H.; Dichgans, M.; Wolf, C.; Dittrich, R.; Touzé, E.; M, S.A.; Samson, Y.; Abboud, S.; Béjot, Y.; Caso, V.; Bersano, A.; Gschwendtner, A.; Sessa, M.; Cole, J.; Lamy, C.; Medeiros, E.; Beretta, S.; H, B.L.; J, G.A.; Michel, P.; J, M.J.; Sharma, P.; Kalashnikova, L.; Nazarova, M.; Larisa, D.; Bartels, E.; Guillon, B.; Evita G, v.H.; Fernandez-Cadenas, I.; Jood, K.; A, N.M.; De Leeuw, F.; Jern, C.; Cheng, Y.; Werner, I.; J, M.A.; Lichy, C.; A, L.P.; Brandt, T.; B, B.G.; Wichmann, H.; Gieger, C.; D, J.A.; Böttcher, T.; Castellano, M.; Arveiler, D.; M, A.I.; B.M.; Padovani, A.; F, M.J.; Kuhlenbäumer, G.; Rolfs, A.; B, W.B.; International Stroke, G.C.; Ringelstein, E.; Zelenika, D.; Tatlisumak, T.; Lathrop, M.; Leys, D.; group, t.C.; Amouyel, P.; Dallongeville, J.

Авторы: Stéphanie Debette, Yoichiro Kamatani, Metso Tiina M., Manja Kloss, Ganesh Chauhan, Engelter Stefan T., Alessandro Pezzini, Vincent Thijs, Markus Hugh S., Martin Dichgans, Christiane Wolf, Ralf Dittrich, Emmanuel Touzé, Southerland Andrew M., Yves Samson, Shérine Abboud, Yannick Béjot, Valeria Caso, Anna Bersano, Andreas Gschwendtner, Maria Sessa, John Cole, Chantal Lamy, Elisabeth Medeiros, Simone Beretta, Bonati Leo H., Grau Armin J., Patrik Michel, Majersik Jennifer J., Pankaj Sharma, Ludmila Kalashnikova, Maria Nazarova, Dobrynina Larisa, Eva Bartels, Benoit Guillon, van den Herik Evita G., Israel Fernandez-Cadenas, Katarina Jood, Nalls Michael A., Frank-Erik De Leeuw, Christina Jern, Yu-Ching Cheng, Inge Werner, Metso Antti J., Christoph Lichy, Lyrer Philippe A., Tobias Brandt, Boncoraglio Giorgio B., Heinz-Erich Wichmann, Christian Gieger, Johnson Andrew D., Thomas Böttcher, Maurizio Castellano, Dominique Arveiler, Arfan Ikram M., Breteler Monique M.B., Alessandro Padovani, Meschia James F., Gregor Kuhlenbäumer, Arndt Rolfs, Worrall Bradford B., Genetics Consortium International Stroke, Erich-Bernd Ringelstein, Diana Zelenika, Turgut Tatlisumak, Mark Lathrop, Didier Leys, the CADISP group, Philippe Amouyel, Jean Dallongeville
Журнал: Nature Genetics
Том: 47
Номер: 1
Год издания: 2015
Издательство: Nature Publishing Group
Местоположение издательства: United Kingdom
Первая страница: 78
Последняя страница: 83
DOI: 10.1038/ng.3154
Аннотация: Cervical artery dissection (CeAD), a mural hematoma in a carotid or vertebral artery, is a major cause of ischemic stroke in young adults although relatively uncommon in the general population (incidence of 2.6/100,000 per year). Minor cervical traumas, infection, migraine and hypertension are putative risk factors, and inverse associations with obesity and hypercholesterolemia are described. No confirmed genetic susceptibility factors have been identified using candidate gene approaches. We performed genome-wide association studies (GWAS) in 1,393 CeAD cases and 14,416 controls. The rs9349379[G] allele (PHACTR1) was associated with lower CeAD risk (odds ratio (OR) = 0.75, 95% confidence interval (CI) = 0.69-0.82; P = 4.46 × 10(-10)), with confirmation in independent follow-up samples (659 CeAD cases and 2,648 controls; P = 3.91 × 10(-3); combined P = 1.00 × 10(-11)). The rs9349379[G] allele was previously shown to be associated with lower risk of migraine and increased risk of myocardial infarction. Deciphering the mechanisms underlying this pleiotropy might provide important information on the biological underpinnings of these disabling conditions.
Добавил в систему: Назарова Мария Александровна

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COMMON VARIATION IN PHACTR1 IS ASSOCIATED WITH SUSCEPTIBILITY TO CERVICAL ARTERY DISSECTIONстатья