Аннотация:Traumatic brain injury (TBI) causes neurologic deficit in 70% of survivors
without a clinically effective therapy. Transcranial direct current stimulation
(tDCS) is a prospective adjunct therapy for TBI but due to limited
animal studies the mechanisms and optimal parameters are unknown. In
this pilot study we examined the effects of repetitive anodal tDCS on cerebral
blood flow (CBF) and brain oxygenation after TBI in mice and
evaluated the efficacy in long-term neurologic recovery. Using in-vivo 2-
photon laser scanning microscopy (2PLSM) we have shown that tDCS (0.1
mA/15min) improved microvascular CBF and tissue oxygenation in the
pericontusional cortex in the recovery period after TBI, which was
confirmed by global CBF by magnetic resonance imaging (MRI). Repetitive
tDCS (4 weeks, 4 days/ week) significantly improved motor and cognitive
neurologic outcome. tDCS acutely increases CBF and tissue oxygenation
and contributes to improved neurologic recovery after TBI.