Polymorphism in 4’-Hydroxyacetophenone: The full Picture from 0 K to Fusion

Bernardes Carlos, E.S.; Melo Pedro, L.T.; Ilin, D.Y.; Lukyanova, V.A.; Druzhinina, A.I.; Minas da Piedade, M.E.

Авторы: Bernardes Carlos E.S, Melo Pedro L.T, Ilin Dima Yu, Lukyanova Vera A., Druzhinina Anna I., Minas da Piedade Manuel E.
Сборник: Book of Abstracts of 50th Annual Conference The British Association for Crystal Growth, 9-11 July 2019
Тезисы
Год издания: 2019
Место издания: Great Britain, London
Первая страница: 62
Аннотация: 4’-Hydroxyacetophenone (HAP, Figure 1a) has, in the last decade, emerged in our group as an excellent model to investigate diverse aspects of polymorphism and crystallization. Two polymorphs and three hydrates have been identified up to now, and characterized from structural, stability domains, solid state transitions and crystallization points of view.1-6 Solubility studies demonstrated that the two polymorphs (Form I, monoclinic, P21/c, Z’ = 1 and Form II, orthorhombic, P212121, Z’ = 2) are enantiotropically related by a solid-solid phase transition at ~303 K, where packing, molecular conformation, and Z’ simultaneously change. Reversible interconversion of both forms at that temperature only occurs, however, under slurry conditions. Indeed, due to high kinetic barriers5, the Form II → Form I transition can only be detected in the solid state, if the sample is heated to temperatures significantly above 303 K (i.e. metastable zone widths of 30-60 K, depending on the heating rate) and the reverse process has never been observed.
Добавил в систему: Дружинина Анна Ивановна

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