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Comparative Analysis of Suppression of Seizures by Neurotransplantation in Different Strains of Rats with Genetic Epilepsyстатья
Дата последнего поиска статьи во внешних источниках: 28 февраля 2020 г.
- Авторы: Ermakova I., Kuznetsova G., Loseva E., Petrova E.V., Ioffe M.E.
- Журнал: Epilepsia
- Том: 37
- Номер: S3
- Год издания: 1996
- Издательство: Blackwell Publishing Inc.
- Местоположение издательства: United Kingdom
- Первая страница: 117
- Последняя страница: 117
- DOI: 10.1111/j.1528-1157.1996.tb01721.x
- Аннотация: Comparative Analysis of Suppression of Seizures by Neurotrans- plantation in Different Strains of Rats with Genetic Epilepsy. Irina Ermakova, G. D. Kuznetsova, E. V. Loseva, E. V. Petrova, and M. E. Ioffe (Institute of Higher Nervous Activity, Moscow, Russia). The influence of neurotransplantation on audiogenic seizures (AS) was studied for 9 months. Three strains of rats with AS were used: Wistar rats, which showed a middle level of epileptic sensitivity; Krushinski-Molodkina (KM) rats with strong AS; and WAG/Rij rats with some AS and spike-wave discharges, charac- teristic of generalized absence epilepsy. The neural tissue for transplantation was taken from embryonal and newborn brain. Solid grafts of different structures of the donor brain (cerebellum, cortex, amygdala, hippocampus, and striatum) or from two of these structures were used for transplantation. In all cases, the grafts were transplanted bilaterally into the parietal cortex. The most successful combination in Wistar rats was the transplantation of the striatum + cerebellum from the newborn brain. Complete cessation of AS was noted in 70% of the animals. The suppressive effect was weaker (-30%) and was not significant in comparison with the control group when the same combination was taken from the embryonic brain. The separate transplantations of striatum or cerebellum had slight effects. In KM rats, a considerable increase in the latency of AS and some decrease in their intensity was observed after the striatum + cerebellum transplantation. However, grafting of striatum and ST+CR in WAG/Rij caused an increase in AS. In all, the present data demonstrate the feasibility of this approach and equally well demonstrate the necessity for subsequent search for adequate variants of the grafting for different types of genetic epilepsy.
- Добавил в систему: Иоффе Марат Евсеевич