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Production of stable cell lines on the basis of the cultured RPMI 8866 B-cells with constant and inducible expression of the Human Immunodeficiency Virus Tat proteinстатья
Информация о цитировании статьи получена из
Web of Science
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 27 февраля 2020 г.
- Авторы: Gorbacheva M.A., Tikhomirova M.A., Potashnikov D.M., Akbay B., Sheval E.V., Musinova Y.R.
- Журнал: Russian Journal of Developmental Biology
- Том: 50
- Номер: 5
- Год издания: 2019
- Издательство: Springer Verlag
- Местоположение издательства: Germany
- Первая страница: 275
- Последняя страница: 280
- DOI: 10.1134/S1062360419050060
- Аннотация: Highly-efficient antiretroviral therapy allows controlling human immunodeficiency virus (HIV) and preventing the development of immunodeficiency. However, the patients who receive therapy may develop different complications, including B-cell lymphomas. One of oncogenesis’ mechanisms in HIV-infected patients is associated with the activity of the viral Tat protein, which is able to penetrate into B-cells. In order to study the effect of the Tat protein on B-cells, a report is given on the production and characterization of the cell lines based on the cultured RPMI 8866 B-cell line demonstrating constant and inducible expression of the Tat protein.
- Добавил в систему: Шеваль Евгений Валерьевич