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Synthesis of Isoxazolines from Nitroalkanes via a [4+1]-Annulation Strategyстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Ushakov Pavel, Khatuntseva Elizaveta, Nelyubina Yulia, Tabolin Andrey, Ioffe Sema L., Sukhorukov Alexey
- Журнал: Advanced Synthesis and Catalysis
- Год издания: 2019
- Издательство: John Wiley & Sons Ltd.
- Местоположение издательства: United Kingdom
- DOI: 10.1002/adsc.201901000
- Аннотация: A novel access to isoxazolines was developed using the [4+1]‐annulation of α‐keto‐stabilized sulfur ylides with N,N‐bis(siloxy)enamines derived from aliphatic nitro compounds. The resulting 5‐keto‐substituted isoxazolines were shown to be convenient precursors of polysubstituted 3‐hydroxypyrrolidines via the one‐pot catalytic N‐O hydrogenolysis/intramolecular reductive amination sequence. Application of this approach to the formal synthesis of Merck’s potent NK1 receptor antagonist was demonstrated.
- Добавил в систему: Сухоруков Алексей Юрьевич