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Pregnancy in WAG/Rij rats-changes in the levels of progesterone, estradiol and generalized absence epilepsyстатья Исследовательская статья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 1 апреля 2020 г.
- Авторы: Chepurnov SA, Chepurnova NE, Tolmacheva EA, Kochetkov IaA, van Luijtelaar EL, Coenen AM
- Журнал: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk
- Том: 88
- Номер: 6
- Год издания: 2002
- Издательство: NAUKA
- Местоположение издательства: SHUBINSKII PEREULOK 10, MOSCOW, RUSSIA, G-200
- Первая страница: 741
- Последняя страница: 750
- Аннотация: Progesterone and oestradiol serum level was investigated in WAG/Rij rats with genetically determined absences. Blood samples were drawn before and after the pregnancy following the parturition. The serum concentration of progesterone increased after the 3rd day of pregnancy. There is no increasing of oestradiol during pregnancy as large as this. The progesterone is kept high to the 18th day of pregnancy and drastically decreased before the parturition. Common duration of absences--spontaneous spikewave discharges (SWD), frequency and the duration of every SWD decreased from 3rd to 19th days of pregnancy before the parturition. On the basis of these data and modern investigations, regulation of GABAA receptor expression during pregnancy by progesterone (Brusaartd A. B. et al., 1999) it can be assumed that the changes in the parameters of SWD are possibly correlated with the progesterone changes in serum during pregnancy in WAG/Rij rats.
- Добавил в систему: Толмачева Елена Александровна