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Demographic approaches to the study of aging on cell culturesстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 31 июля 2020 г.
- Авторы: Khokhlov A.N., Morgunova G.V., Klebanov A.A.
- Журнал: Moscow University Biological Sciences Bulletin
- Том: 74
- Номер: 4
- Год издания: 2019
- Издательство: Allerton Press
- Местоположение издательства: New York, N.Y., United States
- Первая страница: 262
- Последняя страница: 267
- DOI: 10.3103/S0096392519040060
- Аннотация: Aging organisms die out in accordance with the "Gompertz law", i.e. the probability of their death increases with age. Survival curve construction is the main tool for gerontologists to study aging and test anti-aging drugs. The analysis of survival curves includes obtaining some indicators characterizing the aging of the population, for example, average and maximum life span, mortality rate, and aging rate. Testing of geroprotectors can be correctly performed only by obtaining such curves. The dying out of stationary cell populations – bacteria, yeast, and mammalian cell culture – also occurs in accordance with the Gompertz equation. In this regard, it is reasonable to use the construction of survival curves and their analysis to study the "aging" of non-subcultured cell cultures and testing of anti-aging drugs on them. We used this approach in our own experiments, due to which we were able to detect the positive geroprotective effect of the Quinton Marine Plasma on stationary phase aging culture of Chinese hamster cells.
- Добавил в систему: Хохлов Александр Николаевич