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ANTI-TUMOR EFFICACY of OZONE-PHOTODYNAMIC THERAPY AND ITS IMPACT ON FREE-RADICAL HOMEOSTASIS IN EXPERIMENTAL NEOPLASIAстатья
- Авторы: Shcherbatyuk T.G., Plekhanova E.S., Chernigina I.A., Gapeyev A.B.
- Журнал: Вестник физиотерапии и курортологии
- Том: 25
- Номер: 3
- Год издания: 2019
- Первая страница: 39
- Последняя страница: 40
- Аннотация: Abstract. The study presents experimental data on the combined application of ozonized physiological solution with a low concentration of ozone and photodynamic therapy with the intratumoral introduction of the photosensitizer "Photosens". Anti-tumor efficacy of the developed treatment regimen, as well as the correction of free radical processes in tumor-bearing animals and low genotoxic effect were shown. Key words: ozone, photodynamic therapy, free radical processes, comet assay, cancer. Conclusions The experimental scheme of ozone-photodynamic therapy developed causes tumor regression and has a reduced risk of stimulating the tumor growth compared to mono-PDT. The protection effect of the combined action of PDT and OPS is manifested as a decrease in the level of DNA damage in normal cells. The work was supported by the Russian Foundation for Basic Research (project 19-02-00667). References 1. van Straten D., Mashayekhi V., de Bruijn H.S., Oliveira S., Robinson D.J. 2017. Oncologic photodynamic therapy: Basic principles, current clinical status and future directions. Cancers (Basel). 9(2), pii E19. 2. Shcherbatyuk T.G. Free radical processes and its correction in animals with experimental neoplasia. Thesis of Dr. Sci. Nizhniy Novgorod, 2003 (in Russian). 3. Shcherbatyuk T.G., Plekhanova E.S., Chernigina I.A. The method of photodynamic therapy of malignant tumors in the experiment. Patent RUS №2680220/18.02.19. Byul. №5 (in Russian). https://edrid.ru/rid/219.016.c56d.html. 4. Yaroslavtseva-Isaeva E.V., Kaplan M.A., Romanko Ju.S., Sokol N.I. 2013. Development of methods for photodynamic therapy of experimental tumor (sarcoma M-1) with local administration of photosensitizer. Russian Biotherapeutic J. 2(4), 19-22 (in Russian). 5. Kuz'mina Ye.I., Nelyubin A.S., Shchennikova M.K. The use of induced chemiluminescence to assess free radical reactions in biological substrates // in Interuniversity Collection "Biochemistry and Biophysics of Microorganisms". - Gor'kiy, 1983. - P. 179-183 (in Russian). 6. Sirota N.P., Kuznetsova E.A. 2010. The comet assay application in radiobiological investigations. Radiation Biology. Radioecology. 50(3), 329-339 (in Russian). 7. Arutyunyan A.V., Dubinina Ye.Ye., Zybina N.N. Methods for evaluating free radical oxidation and the antioxidant system of the body. St. Petersburg: IKF "Foliant"; 2000 (in Russian).
- Добавил в систему: Щербатюк Татьяна Григорьевна