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Hand and neck movement related pallidal single-unit activity in isolated cervical dystoniaтезисы доклада
- Авторы: Sedov A., Popov V., Usova S., Tomskiy A., Shaikh A.
- Сборник: Abstract book of XIIIth IBAGS Meeting, April 28 - May 2, 2019, Biarritz, France
- Тезисы
- Год издания: 2019
- Место издания: International Basal Ganglia Society
- Первая страница: 150
- Последняя страница: 150
- Аннотация: Cervical dystonia (CD), the most common form of focal dystonia is characterized by abnormal head posture combined with jerky or tremulous movements. The mechanistic underpinning of this common disorder remains unclear. One of the theories suggests increased activity through cortico-striato-pallidal “direct” and “indirect” pathway as a cause of dystonia. Reduced pallidal output, changes in firing pattern and long-lasting inhibition induced by cortical stimulation was previously described. The aim of our study was to characterize evoked single-unit activity in response to voluntary movement of affected (dystonic) neck muscles and compare it with unaffected (clinically normal) hand movement. We used microelectrode recording from 12 CD subjects undergoing deep brain stimulation (DBS) surgery under local anesthesia. We analyzed 45 neck and 21 hand movement sensitive neurons, recorded from GPi and GPe. Comparison of single-unit response with electromyography (EMG) revealed either lead or lag in neural response. Some neurons responded by short-term phasic activation (or inhibition) as a rule initiating movement and other cells characterized by long-term tonic responses. Some neurons responded with both lead and lag excitatory-inhibitory components accompanied by low frequency (1-5 Hz) oscillations. Comparison between hand and neck movement showed several differences. About 50% of neck sensitive cells responded with prolonged inhibition while most hand movements responded by excitation. Wherein in contrast to hand responses, all neck responses had an exponential decay with comparable to EMG decay time constant. Such decay in neuronal response was characterized by the time constant comparable to the one explained by previously described abnormal head neural integrator controlling head position.
- Добавил в систему: Гамалея Анна Александровна