Аннотация:Lateralized differences in pallidal outflow is assumed to be linked with asymmetric
pathological tension of the neck muscles in cervical dystonia (CD) patients. At the
population level the interhemispheric asymmetry was usually studied regarding the
estimation of the spectral power in specified frequency bands, without taking in
consideration the broadband spectral features. Nowadays, it was showed that the 1/f
broadband activity is a neurophysiological indicator of excitation/inhibition ratio (Gao
et al., 2017).
In view of these concerns, we recorded pallidal LFPs bilaterally in seven CD patients
with combined latero- and torticollis and examined how lateralized asymmetry
impacts on the 1/f broadband activity. LFPs was recorded intraoperatively during
DBS surgery. All patients showed a trend towards an asymmetric difference in the 1/f
broadband activity. Ipsilateral 1/f slope was greater in both GPi and GPe than
contralateral, along with the prominent correlation between GPi and GPe slopes. We
found that torticollis and the interaction between torti- and laterocollis had a strong
impact on the 1/f broadband asymmetry, while only laterocollis had almost no
significant influence.
Our findings emphasize the importance of mainstreaming a broadband activity in the
estimation of LFP spectral features and provide further evidence for the pallidal
asymmetry in CD patients.
This study was supported by Russian Foundation for Basic Research (RFBR) (18-
315-00202)
Keywords: dystonia, LFP, globus pallidus
1) Gao, R., Peterson, E.J., Voytek, B., 2017. Inferring synaptic excitation/inhibition
balance from field potentials. NeuroImage 158, 70–78