Functionalized calcium orthophosphates (CaPO4) and their biomedical applicationsстатья
Статья опубликована в высокорейтинговом журнале
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Дата последнего поиска статьи во внешних источниках: 24 января 2020 г.
Аннотация:Due to the chemical similarity to natural calcified tissues (bones and teeth) of mammals, calcium
orthophosphates (abbreviated as CaPO4) appear to be good biomaterials for creation of artificial bone
grafts. However, CaPO4 alone have some restrictions, which limit their biomedical applications. Various
ways have been developed to improve the properties of CaPO4 and their functionalization is one of
them. Namely, since surfaces always form the interfaces between implanted grafts and surrounding
tissues, the state of CaPO4 surfaces plays a crucial role in the survival of bone grafts. Although the
biomedically relevant CaPO4 possess the required biocompatible properties, some of their properties
could be better. For example, functionalization of CaPO4 to enhance cell attachment and cell material
interactions has been developed. In addition, to prepare stable formulations from nanodimensional
CaPO4 particles and prevent them from agglomerating, the surfaces of CaPO4 particles are often
functionalized by sorption of special chemicals. Furthermore, there are functionalizations in which
CaPO4 are exposed to various types of physical treatments. This review summarizes the available
knowledge on CaPO4 functionalizations and their biomedical applications.