Sex-specific effect of NRXN1 and NRG1 genes polymorphisms on individual differences in working memoryстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 24 января 2020 г.
Аннотация:Working memory capacity represents the amount of information that can be temporarily maintained in an accessible state, making it useful for many cognitive tasks. Previously, it was suggested that individual differences in working memory are caused by both genetic and environmental factors. Differences in synaptic plasticity represent the most important neurochemical basis for learning and memory formation. Since neurexin 1 (NRXN1) and neuregulin 1 (NRG1) as cell adhesion molecules are involved in the regulation of synaptic plasticity, examination of NRXN1 and NRG1 genes with respect to cognitive parameters is of interest. The present study aimed to estimate the main effect of NRG1 (rs6994992) and NRXN1 (rs1045881 and rs4971648) gene polymorphisms on working memory capacity measured with the Corsi Blocks task. The study involved 288 mentally healthy individuals of Caucasian origin (Russians, Tatars) from Republic of Bashkortostan (75% women) (mean age 20.3 ± 3.87 years). A written inform consent was obtained from all the participants after they were acquainted with all the procedures. SNPs genotyping was performed via real-time PCR based on TaqMan technology (TestGen, Russia). Statistical analysis was conducted with Plink v.1.07. The results of linear regression analysis indicate the association of NRXN1 rs1045881 minor allele and a higher working memory capacity in the male group (P = 0.02; β = 1.34; r = 8.39), while a decreased working memory capacity was observed in females bearing NRG1 rs6994992 T-allele (P = 0.005; β = - 0,92; r = 3,62).