Insertion of an unnatural amino acid into the protein structure: preparation and properties of 3-fluorotyrosine-containing organophosphate hydrolaseстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
Аннотация:Five Tyr residues present in the native organophosphate hydrolase (OPH) containing a hexahistidine tag at the N-terminus of the protein molecule (His(6)-OPH) were replaced by fluorine-containing analogs using a biosynthetic approach. The modified enzyme had an extended pH-optimum of action shifted to acidic pH and an enhanced thermal stability in the alkaline pH region