Metal Nanoparticle Containing Nanocomposites   of Drug Substances and Their Potential   Biomedical Applications

Shabatina, T.I.; Vernaya, O.I.; Shabatin, V.P.; Melnikov, M.Y.; Semenov, A.M.; Lozinsky, V.I.

Информация о цитировании статьи получена из Web of Science, Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 1 апреля 2020 г.

Авторы: Shabatina Tatyana I., Vernaya Olga I., Shabatin Vladimir P., Melnikov Michail Y., Semenov Alexandr M., Lozinsky Vladimir I.
Журнал: Applied Sciences
Том: 10
Номер: 170
Год издания: 2020
Издательство: Universitatea Politehnica Bucuresti
Местоположение издательства: Romania
Первая страница: 1
Последняя страница: 11
DOI: 10.3390/app10010170
Аннотация: New hybrid nanosystems containing the antibacterial substances dioxidine or gentamicin sulfate with bioactive metal (Ag, Cu) nanoparticles have been obtained by a cryogenic freeze-drying method and incorporate further the nanocomposites thus obtained into the cryogenically structured biopolymeric matrices based on gelatin, calcium alginate, and chitosan. FTIR, UV-visible, and NMR spectroscopy, TEM and SEM microscopy data show that the resulting systems consist of wide-porous polymer sponges (pore diameters, 10–200 μm) that contain antibacterial drugs and silver (2–30 nm) or copper (1–5 nm) nanoparticles. The investigation showed that these systems ensure a gradual release of dioxidine (from 40 min up to 3 days), depending on the nature of the matrix and its microstructure. The higher activity of hybrid composites based on nanometals and dioxidine or incorporated into cryostructured biopolymer matrices against the bacterial strains of Escherichia coli 52, Staphylococcus aureu s 144 is demonstrated as compared to the individual components in the same matrices.
Добавил в систему: Верная Ольга Ивановна

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Metal Nanoparticle Containing Nanocomposites of Drug Substances and Their Potential Biomedical Applicationsстатья

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