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Low-molecular-weight inhibitors of NF-κB signalling pathwaysстатья
- Авторы: Dolinnaya N.G., Kubareva E.A., Kazanova E.V., Zigangirova N.A., Naroditsky B.S., Gintsburg A.L., Oretskaya T.S.
- Журнал: Uspekhi khimii, издательство MEZHDUNARODNAYA KNIGA, 39 DIMITROVA UL., 113095 MOSCOW, RUSSIA
- Том: 77
- Номер: 11
- Год издания: 2008
- Первая страница: 1036
- Последняя страница: 1052
- Аннотация: The nuclear factor κB (NF-κB) is a transcription factor involved in inducible expression of cellular genes playing a key role in cardiovascular pathologies, carcinogenesis, inflammatory and viral diseases. The review describes the stimuli and processes inducing NF-κB activation and the components of a signalling cascade that could constitute targets for NF-κB inhibition. The molecular action and properties of various low-molecular weight inhibitors aiming to prevent NF-κB activity are summarised.
- Добавил в систему: Долинная Нина Германовна