Аннотация:The aim of study was in evaluable the immunogenicity of covalent conjugates recombinant nonstructural NS4 and NS5A of hepatitis C virus (HCV) proteins with peptidoglycane Immunomax(sic), which displays immunomodulating activity. BALB/c and DBA/2J mice were immunized intraperitoneally 2 times at a month interval with different doses (0.1 - 2 mu g/mouse) of the proteins without adjuvants, as conjugates with Immunomax, or with complete Freund's adjuvant. The NS4-Immunomax conjugate induced high antibody production at low protein doses (<2 mu g), the other combinations were not immunogenic at given doses. Only the conjugate induced splenic accumulation of T cells specifically reacting in vitro with different NS5A antigens by cell proliferation and/or cytokine secretion.