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Patterns of Aging Biomarkers, Mortality, and Damaging Mutations Illuminate the Beginning of Aging and Causes of Early-Life Mortalityстатья Исследовательская статья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 29 января 2020 г.
- Авторы: Kinzina Elvira D., Podolskiy Dmitriy I., Dmitriev Sergey E., Gladyshev Vadim N.
- Журнал: Cell reports
- Том: 29
- Номер: 13
- Год издания: 2019
- Издательство: Cell Press
- Местоположение издательства: United States
- Первая страница: 4276
- Последняя страница: 4284.e3
- DOI: 10.1016/j.celrep.2019.11.091
- Аннотация: An increase in the probability of death has been a defining feature of aging, yet human perinatal mortality starts high and decreases with age. Previous evolutionary models suggested that organismal aging begins after the onset of reproduction. However, we find that mortality and incidence of diseases associated with aging follow a U-shaped curve with the minimum before puberty, whereas quantitative biomarkers of aging, including somatic mutations and DNA methylation, do not, revealing that aging starts early but is masked by early-life mortality. Moreover, our genetic analyses point to the contribution of damaging mutations to early mortality. We propose that mortality patterns are governed, in part, by negative selection against damaging mutations in early life, manifesting after the corresponding genes are first expressed. Deconvolution of mortality patterns suggests that deleterious changes rather than mortality are the defining characteristic of aging and that aging begins in very early life.
- Добавил в систему: Дмитриев Сергей Евгеньевич