Comparative assessment of sorbic and benzoic acid via express biotestстатья
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Дата последнего поиска статьи во внешних источниках: 17 июля 2020 г.
Аннотация:Negative physiological and biochemical effects of chronic and subchronic doses of benzoates and sorbates may pose a
certain risk to human health. Identifying new biomarkers responsible for the body’s response to these compounds could provide
significant details in determining the mechanism of their toxicity. To assess comparatively physiological, cytological, cytogenetic,
and biochemical parameters in onion roots cells we used an Allium test. The roots were previously treated with sorbic and benzoic
acids. The study recorded the dose-dependent toxic effect of these preservatives on the root mass growth. The EC50 values obtained for
benzoic and sorbic acids (10 mg/L and 110 mg/L respectively) were significantly lower than the regulated concentrations prescribed
by the standards for their content in certain types of food products. With an increase in concentrations of these acids, the mitotic
index of meristematic cells decreased in experimental groups compared to control groups. The data obtained confirmed the necessity
of estimating the mitotic index when choosing onion for the Allium test. The necessity resulted from the fact that low proliferative
activity could cause false positive results. Sorbic and benzoic acids in concentrations below the corresponding EC50 increased the
frequency of chromosomal aberrations in apical meristematic cells of the roots compared to control. Thus, benzoic and sorbic acids
had reliable mitodepressive and genotoxic effects on the dividing cells of onion roots. The study explored the dynamics of lipid
oxidation biomarker accumulation (malon dialdehyde, MDA) after exposure to benzoic and sorbic acids. The toxic effect of benzoic
acid appeared not to be associated with oxidative damage to root cell lipids, whereas sorbic acid in concentrations from 20 to 200 mg/L
resulted in a multiple increase in MDA concentration in the test samples compared to control. At the same time, lipid peroxidation
showed a higher level of sensitivity compared to other indicators of this test. Further, the data obtained on the toxic influence of sorbic
and benzoic acids can be used in express methods to assess food and ecological security of these acids.