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Interaction of C60 fullerene complexed to doxorubicin with model bilipid membranes and its uptake by HeLa cellsстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 27 сентября 2016 г.
- Авторы: Prylutskyy Yu, Bychko A., Sokolova V., Prylutska S., Evstigneev M., Rybalchenko V., Epple M., Scharff P.
- Журнал: Materials Science and Engineering C
- Том: 59
- Год издания: 2016
- Первая страница: 398
- Последняя страница: 403
- DOI: 10.1016/j.msec.2015.10.049
- Аннотация: With an aim to elucidate the effects of C60 fullerene complexed with antibiotic doxorubicin (Dox) on model bilipid membranes (BLM), the investigation of the electrical properties of BLM under the action of Dox and C60 fullerene, and of their complex, C60+ Dox,was performed. The complex aswell as its components exert a clearly detectable influence on BLM, which is concentration-dependent and also depends on phospholipid composition. The mechanism of this effect originates either from intermolecular interaction of the drug with fatty-acid residues of phospholipids, or from membranotropic effects of the drug-induced lipid peroxidation, or from the sum of these two effects. By fluorescence microscopy the entering of C60 + Dox complex into HeLa cells was directly shown. © 2015 Elsevier B.V. All rights reserved.
- Добавил в систему: Евстигнеев Максим Павлович