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Radical Trideuteromethylation with Deuterated Dimethyl Sulfoxide in the Synthesis of Heterocycles and Labelled Building Blocksстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Caporaso Roberta, Manna Srimanta, Zinken Sarah, Kochnev Alexander R., Lukyanenko Evgeny, Kurkin Alexander V., Antonchick Andrey P.
- Журнал: Chemical Communications
- Год издания: 2016
- Издательство: Royal Society of Chemistry
- Местоположение издательства: United Kingdom
- DOI: 10.1039/c6cc07196a
- Аннотация: The potential of deuterated pharmaceuticals is being widely demonstrated since several deuterium-containing drugs have reached clinical trials. The methyl group is one of the most frequently occurring groups in the drugs and has impressive effect on biological activity of drugs. Here we describe the first trideuteromethylation under radical reaction conditions using deuterated dimethyl sulfoxide as reagent for the synthesis of labelled heterocycles and trideuteromethylated compounds. A broad scope of developed method for the synthesis of various scaffolds was demonstrated.
- Добавил в систему: Куркин Александр Витальевич