[Phylogenesis of steroid-transport proteins in the blood: detection and characteristics of the sex-steroid-binding protein in the blood plasma of the carp]

Авторы: Godovich P.L., Mataradze G.D., Smirnov A.N., Rozen V.B.
Журнал: Probl Endokrinol (Mosk)
Том: 29
Номер: 6
Год издания: 1983
Первая страница: 54
Последняя страница: 59
Аннотация: The interaction of 3H-5 alpha-dihydrotestosterone, 3H-progesterone, 3H-cortisol and 3H-testosterone with the Cyprinus carpio blood proteins was studied by means of adsorption on the activated charcoal and equilibrium dialysis. Protein which specifically binds androgen-, estradiol-, progesterone- and, to a lesser degree, corticosteroids was present in the blood plasma. The equilibrium constants of 3H-steroid association with this protein, the concentration off steroid-binding sites and its hormonal specificity of the affinity were determined. There were no pronounced sex dimorphism and marked alterations in the concentration of protein-binding sites during ontogeny and reproduction process. Protein, being specialized on the corticosteroid transport, was not revealed in the Cyprinus carpio blood plasma. It is suggested that the formation of differentiated corticosteroid-binding globulin and sex steroid-binding protein, typical of higher vertebrates, occurred during the stage of teleostei.
Добавил в систему: Смирнов Александр Николаевич

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