Perfluorocarbon nanoemulsions containing fluorinated photosensitizer for photodynamic cancer therapy

Markova, A.A.; Belyaeva, E.V.; Radchenko, A.S.; Dmitrieva, M.V.; Sigan, A.L.; Shtil', A.A.; Chkanikov, N.D.

Информация о цитировании статьи получена из Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 28 октября 2020 г.

Авторы: Markova A.A., Belyaeva E.V., Radchenko A.S., Dmitrieva M.V., Sigan A.L., Shtil' A.A., Chkanikov N.D.
Журнал: IOP Conference Series: Materials Science and Engineering
Том: 848
Номер: 012054
Год издания: 2020
Издательство: -
Местоположение издательства: Krakow
Первая страница: 1
Последняя страница: 9
DOI: 10.1088/1757-899X/848/1/012054
Аннотация: The composition of the photosensitizer and fluorocarbons with high oxygen capacityallows to increase the effectiveness of photodynamic therapy, which is shown on tumor cells.To achieve the solubility of photosensitizers in fluorocarbons,a number of fluorinatedporphyrins were synthesized and their spectral characteristics were obtained. Fluorocarbonemulsions without a photosensitizer are inert for tumor cells of human colon adenocarcinoma.Fluorocarbon nanoemulsion with leader fluorinated porphyrin with fluoroaliphatic substituentsaccumulates in tumor cells and causes photoinduced necrosis due to peroxidation of membranelipids. Perfluorocarbon nanoemulsions in combination with a dissolved fluorine phasephotosensitizer are promising compositions for the photodynamic therapy of cancer.
Добавил в систему: Маркова Алина Александровна

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Perfluorocarbon nanoemulsions containing fluorinated photosensitizer for photodynamic cancer therapyстатья

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