|
ИСТИНА |
Войти в систему Регистрация |
ИПМех РАН |
||
Huntington's Disease - an Outlook on the Interplay of the HTT Protein, Microtubules and Actin Cytoskeletal Componentsстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 25 ноября 2020 г.
- Авторы: Taran Alexandra S., Shuvalova Lilia D., Lagarkova Maria A., Alieva Irina B.
- Журнал: Cells
- Том: 9
- Номер: 6
- Год издания: 2020
- Издательство: MDPI
- Местоположение издательства: Basel, Switzerland
- Первая страница: 1514
- DOI: 10.3390/cells9061514
- Аннотация: Huntington's disease is a severe and currently incurable neurodegenerative disease. An autosomal dominant mutation in the Huntingtin gene (HTT) causes an increase in the polyglutamine fragment length at the protein N-terminus. The consequence of the mutation is the death of neurons, mostly striatal neurons, leading to the occurrence of a complex of motor, cognitive and emotional-volitional personality sphere disorders in carriers. Despite intensive studies, the functions of both mutant and wild-type huntingtin remain poorly understood. Surprisingly, there is the selective effect of the mutant form of HTT on nervous tissue even, whereas the protein expressed ubiquitously. Huntingtin plays a role in various processes of cell activity: in cell transport, endocytosis, protein degradation, etc. Our experimental data mining let us conclude that a significant part of the huntingtin-involved cellular processes is mediated by microtubules and other cytoskeletal cell structures. The review attempts to look at unresolved issues in the study of the huntingtin and its mutant form, including their functions affecting microtubules and other components of the cell cytoskeleton.
- Добавил в систему: Алиева Ирина Борисовна
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | HD-rev-2020_Cells.pdf | HD-rev-2020_Cells.pdf | 951,6 КБ | 23 июня 2020 [AlievaIB] |