Synthesis and biological evaluation of novel dispiro compounds based on 5-arylidenehydantoins and isatins as inhibitors of p53–MDM2 protein–protein interactionстатья
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Дата последнего поиска статьи во внешних источниках: 19 августа 2020 г.
Аннотация:A series of novel hydantoin-based dispiroindolinones as potential small-molecule inhibitors of p53–MDM2 protein–protein interactionwere synthesized by two methods, using 2-arylidenehydantoins as starting materials. Some compounds demonstrate moderatecytotoxicity against cancer cell lines with IC50 in micromolar concentration range, which is comparable to nutlin-3. Two of thesynthesized dispiroindolinones show p53-related activity in p53 reporter activation test.