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Surfactant-free tantalum oxide nanoparticles: synthesis, colloid properties, and application as a contrast agent for computed tomographyстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 7 октября 2020 г.
- Авторы: Koshevaya Ekaterina, Koshevaya Ekaterina, Koshevaya Ekaterina, Nazarovskaia Daria, Simakov Matvey, Simakov Matvey, Simakov Matvey, Belousov Alexandr, Morozov Vladimir, Gandalipov Erik, Krivoshapkina Elena, Krivoshapkina Elena, Krivoshapkin Pavel, Krivoshapkin Pavel, Krivoshapkin Pavel
- Журнал: Journal of Materials Chemistry B
- Том: 8
- Год издания: 2020
- Первая страница: 8337
- Последняя страница: 8345
- DOI: 10.1039/D0TB01204A
- Аннотация: With the growing interest of the medical industry in biocompatible nanoparticles (NPs), the current synthetic methods should be adapted to appropriate demands (toxicity, scalability, etc.). Most applications require colloidal systems to be stable not only in water but also in vivo, which represents a major challenge. In this study, biocompatible Ta2O5 NPs were synthesized by a solvothermal method avoiding toxic reagents, and surfactant-free stable hydrosols were obtained and used for computed tomography (CT) imaging. The small hydrodynamic size (2 nm) and colloidal stability of primary NPs were studied by dynamic light scattering (DLS). The particles were characterized by X-ray diffraction, transmission electron microscopy, energy-dispersive X-ray spectroscopy, and Brunauer–Emmett–Teller analysis to confirm their structure and purity. To develop a stable hydrosol preparation protocol, the influence of pH and ultrasonication duration on the stability of Ta2O5 sols was analyzed by DLS and microelectrophoresis. To enhance the understanding of NP behavior in vivo, sol stability in conditions close to physiological (NaCl solutions) was studied in a pH range of 3–9. Hydrosols prepared by the proposed protocol were stable for at least 6 months and exhibited negligible cytotoxicity. Ta2O5 NPs also showed high CT contrast both in theoretical calculations and in vivo (rat gastrointestinal tract).
- Добавил в систему: Белоусов Александр Витальевич