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Biotransformation of the antibacterial agent cinoxacin by the fungus Beauveria bassianaстатья
Информация о цитировании статьи получена из
Scopus,
Web of Science
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
- Авторы: Parshikov I.A., Heinze T.M., Williams A.J., Moody J.D., Freeman J.P., Sutherland J.B.
- Журнал: FEMS Microbiology Letters
- Том: 214
- Номер: 1
- Год издания: 2002
- Издательство: Blackwell
- Местоположение издательства: United Kingdom
- Первая страница: 133
- Последняя страница: 136
- DOI: 10.1111/j.1574-6968.2002.tb11336.x
- Аннотация: The ability of the fungus Beauveria bassiana ATCC 7159 to transform the antibacterial agent cinoxacin was investigated. Cultures in sucrose–peptone broth were dosed with cinoxacin, grown for 20 days, and then extracted with ethyl acetate. Two metabolites were detected and purified by high-performance liquid chromatography. The major metabolite was identified by mass and proton nuclear magnetic resonance spectra as 1-ethyl-1,4-dihydro-3-(hydroxymethyl)[1,3]dioxolo[4,5-g]cinnolin-4-one and the minor metabolite was identified as 1-ethyl-1,4-dihydro-6,7-dihydroxy-3-(hydroxymethyl)cinnolin-4-one. B. bassiana also reduced quinoline-3-carboxylic acid to 3-(hydroxymethyl)quinoline.
- Добавил в систему: Паршиков Игорь Альбертович