Biocatalysis of the antimalarial artemisinin by Mucor ramannianus strainsстатья
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Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
Аннотация:Biocatalysis of artemisinin by different strains of Mucor ramannianus.* illustrates a simple approach to bioengineering for attaining useful biotransformation strains for preparative or downstream development. Three different strains of M. ramannianus. on the malt/sucrose medium were compared for their native ability to metabolize the antimalarial artemisinin and produce significant yields of hydroxylated artemisinin derivatives. The M. ramannianus. strains transformed the antimalarial into hydroxylated metabolites, in particular 7β.-hydroxyartemisinin at 88% yield and 6β.-hydroxyartemisinin at 51% yield.
M. ramannianus. strains: M. ramannianus. 1839, University of Wisconsin, M. ramannianus. ATCC 9624, American Typical Cultures Collection, M. ramannianus. ATCC MYA-883 (R-56), Jefferson County, Arkansas (American Typical Cultures Collection).