Multisite cell‐ and neural‐dynamics‐resolving deep brain imaging in freely moving mice with implanted reconnectable fiber bundlesстатья
Статья опубликована в высокорейтинговом журнале
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Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 30 сентября 2020 г.
Аннотация:We demonstrate a reconnectable implantable ultraslim fiber‐optic microendoscope that integrates a branching fiber bundle (BFB) with gradient‐index fiber lenses, enabling a simultaneous fluorescence imaging of individual cells in distinctly separate brain regions, including brain structures as distant as the neocortex and hippocampus. We show that fluorescence images of individual calcium‐indicator‐expressing neurons in the brain of freely moving transgenic mice can be recorded, via the implanted BFB probe, in parallel with time‐ and cell‐resolved traces of calcium signaling, thus enabling correlated circuit‐dynamics studies at ‐multiple sites within the brain of freely moving animals.