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CONCEPT OF INDIVIDUALIZED MEDICINE BASED ON PERSONALIZED PHAGE THERAPY FOR INTENSIVE CARE UNIT PATIENTS SUFFERING FROM HEALTHCARE-ASSOCIATED INFECTIONSстатья
Статья опубликована в журнале из списка RSCI Web of Science
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из перечня ВАК
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 20 января 2021 г.
- Авторы: ALESHKIN ANDREY V., SHKODA ANDREI S., BOCHKAREVA SVETLANA S., ERSHOVA OL'GA N., MITROKHIN SERGEI D., KISELEVA IRINA A., ZUL'KARNEEV EL'DAR R., RUBAL'SKIY EVGENIY O., NOVIKOVA LIDIYA I., ORLOVA OLGA E., SHVYDKAYA MARIYA G., KALAKUTSKAYA ANNA N., ZEIGARNIK MIKHAIL V., KARAULOV ALEKSANDR V.
- Журнал: Инфекционные болезни
- Том: 15
- Номер: 4
- Год издания: 2017
- Первая страница: 49
- Последняя страница: 54
- Аннотация: Effectiveness of serially produced bacteriophages is high in case of intestinal and respiratory infections caused by community-acquired antimicrobial resistant (AMR) pathogens. However, mass-produced phages don't consider the rapid changes in circulating strains causing HAIs, the formation of anti-phage immunity, phage pharmacokinetics, etc. We have developed an algorithm of personalized phage therapy for ICU patients suffering from HAIs which increases the efficiency of phage therapy by 30 per cent. It consists of three consecutive stages: 1. Determination of sensitivity of target bacterium to bacteriophage preparation; 2. Determination by enzyme-linked immunosorbent assay (ELISA) of IgG-antibodies in the patients' sera active against the phages used; 3. Selection of pharmaceutical form and administration route based on the preliminary phage pharmacokinetics study. Sound and safe update of phage compositions, used against HAI-pathogens, requires the creation of an up-to-date collection of pheno- and genotypically characterized bacteriophages that expect to be included into ready-to-use pharmaceutical forms on the first demand of the hospital.
- Добавил в систему: Воробьева Екатерина Андреевна