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An Approach to Nonsymmetric Bis(tertiary phosphine oxides) Comprising Heterocyclic Fragments via the Pd-Catalyzed Phosphorylationстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 4 ноября 2020 г.
- Авторы: Zakirova Gladis G., Mladentsev Dmitrii Yu, Borisova Nataliya N.
- Журнал: Synlett
- Том: 31
- Номер: 18
- Год издания: 2020
- Издательство: Georg Thieme Verlag
- Местоположение издательства: Germany
- Первая страница: 1833
- Последняя страница: 1837
- DOI: 10.1055/s-0040-1706419
- Аннотация: Nonsymmetric tertiary phosphine oxides with different five- and six-membered heterocyclic fragments such as pyridine, 2,2′-bipyridine, 1,10-phenantroline, quinoline, imidazole, and thiazole were synthesized in good yields via the successive introduction of phosphine oxide groups into the initial dihalogenated heterocycles by means of Pd-catalyzed phosphorylation reaction. The synthesis of pyridine-type compounds is hindered by competing double coupling, while for five-membered heterocycles the principal difficulty is the dehalogenation. Both side processes were successfully suppressed by the use of an excess of a dihalide (which can be easily recovered during the product purification step), proper phosphine ligand for palladium, and nonpolar solvent such as toluene.
- Добавил в систему: Борисова Наталия Евгеньевна