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Increasing the biological activity of benzimidazoles based on the supramolecular nanoscale delivery system with licorice extract against helminthiasisстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 1 февраля 2021 г.
- Авторы: Varlamova A.I., Arkhipov I.A., Khalikov S.S., Arisov M.V., Sadov K.M., Dushkin A.V.
- Журнал: IOP Conference Series: Earth and Environmental Science
- Том: 548
- Год издания: 2020
- Издательство: IOP Publishing
- Местоположение издательства: [Bristol, UK], England
- Первая страница: 1
- Последняя страница: 6
- Номер статьи: 042012
- DOI: 10.1088/1755-1315/548/4/042012
- Аннотация: This paper considers the effect of mechanochemical technology on the anthelminticefficacy of a solid dispersion (SD) of albendazole (ABZ) with licorice extract (LE) / SDALE /,which is considered as a means of targeted delivery. SDALE tests were carried out on white miceexperimentally infected with Trichinella spiralis and Hymenolepis nana and on sheep naturallyinfected with gastrointestinal strongylates and Moniezia expansa cestodes. For eachhelminthiasis, animals of different groups of 9–12 in each were orally administered once a doseof SDALE of 2.0 mg/kg of active substance (AS) in the form of 10–20 % powders and 1 and 2%suspensions in comparison with the basic drug - a substance of albendazole at the dose of 2.0mg/kg. SDALE is prepared by joint milling of similar components (ABZ and LE) in grinderswith adjustable immersion energy (module, time, weight ratio of components, drum rotationspeed) for 2 hours. Animals of the control groups did not receive the drug. The activity of thedrugs was determined according to the data of coproovoscopic examination of sheep by flotationmethod before and 15 days after treatment. SDALE at the dose of 2.0 mg/kg of AS in the formof 10 and 20% powders and 1 and 2% suspensions showed respectively 91.4; 89.3; 87.2 and92.3% efficacy against Nematodirus spp. and 90.7; 88.4; 87.4 and 91.2% activity against othertypes of Strongylata when receiving a 23.2 and 22.7% effect of the base drug - ABZ
- Добавил в систему: Халиков Салават Самадович
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