A Translational Study on Acute Traumatic Brain Injury: High Incidence of Epileptiform Activity on Human and Rat Electrocorticograms and Histological Correlates in Ratsстатья
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Дата последнего поиска статьи во внешних источниках: 25 ноября 2020 г.
Аннотация:Background: In humans, early pathological activity on invasive electrocorticograms (ECoGs)
and its putative association with pathomorphology in the early period of traumatic brain injury (TBI)
remains obscure. Methods: We assessed pathological activity on scalp electroencephalograms (EEGs)
and ECoGs in patients with acute TBI, early electrophysiological changes after lateral fluid percussion
brain injury (FPI), and electrophysiological correlates of hippocampal damage (microgliosis and
neuronal loss), a week after TBI in rats. Results: Epileptiform activity on ECoGs was evident in
86% of patients during the acute period of TBI, ECoGs being more sensitive to epileptiform and
periodic discharges. A “brush-like” ECoG pattern superimposed over rhythmic delta activity and
periodic discharge was described for the first time in acute TBI. In rats, FPI increased high-amplitude
spike incidence in the neocortex and, most expressed, in the ipsilateral hippocampus, induced
hippocampal microgliosis and neuronal loss, ipsilateral dentate gyrus being most vulnerable, a week
after TBI. Epileptiform spike incidence correlated with microglial cell density and neuronal loss in the
ipsilateral hippocampus. Conclusion: Epileptiform activity is frequent in the acute period of TBI
period and is associated with distant hippocampal damage on a microscopic level. This damage is
probably involved in late consequences of TBI. The FPI model is suitable for exploring pathogenetic
mechanisms of post-traumatic disorders.