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Chemical kinetics of the development of coronaviral infection in the human body: Critical conditions, toxicity mechanisms, “thermoheliox”, and “thermovaccinationстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 10 февраля 2021 г.
- Авторы: Varfolomeev S.D., Panin A.A., Bykov V.I., Tsybenova S.B., Chuchalin A.G.
- Журнал: Chemico-Biological Interactions
- Том: 329
- Год издания: 2020
- Издательство: Elsevier BV
- Местоположение издательства: Netherlands
- Первая страница: 109209
- Аннотация: Kinetic modeling of the behavior of complex chemical and biochemical systems is an effective approach to study of the mechanisms of the process. A kinetic model of coronaviral infection development with a description of the dynamic behavior of the main variables, including the concentration of viral particles, affected cells, and pathogenic microflora, is proposed. Changes in the concentration of hydrogen ions in the lungs and the pH -dependence of carbonic anhydrase activity (a key breathing enzyme) are critical. A significant result is the demonstration of an acute bifurcation transition that determines life or system collapse. This transition is connected with exponential growth of concentrations of the process participants and with functioning of the key enzyme carbonic anhydrase in development of toxic effects. Physical and chemical interpretations of the therapeutic effects of the body temperature rise and the potential therapeutic effect of “thermoheliox” (respiration with a thermolized mixture of helium and oxygen) are given. The phenomenon of “thermovaccination” is predicted, which involves stimulation of the immune response by thermoheliox”.
- Добавил в систему: Быков Валерий Иванович