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Safety and Short-Term Oncological Outcomes of Thulium Fiber Laser En Bloc Resection of Non-Muscle-Invasive Bladder Cancer: A Prospective Non-Randomized Phase II Trialстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 30 сентября 2020 г.
- Авторы: Enikeev Dmitry, Taratkin Mark, Margulis Vitaly, Sorokin Nikolay, Severgina Lubov, Paramonova Nina, Kislyakov Dmitry, Kozlov Vasiliy, Rapoport Leonid, Shariat Shahrokh F.
- Журнал: Bladder Cancer
- Том: 6
- Номер: 2
- Год издания: 2020
- Издательство: IOS Press
- Местоположение издательства: Amsterdam, Netherlands
- Первая страница: 201
- Последняя страница: 210
- DOI: 10.3233/BLC-200275
- Аннотация: Ongoing efforts aim at overcoming the challenges of conventional transurethral resection of bladder tumor (TURBT) such as the high recurrence rate, difficulty of pathologic interpretation and complications including wall injury.OBJECTIVE:To prospectively assess the safety and efficacy of Thulium fiber en bloc resection of bladder tumor (Tm-fiber ERBT) compared to TURBT.RESULTS:RFS rates at 3 and 6 months were 84.5% and 67.2% for conventional TURBT versus 97.2% and 91.5% for Tm-fiber ERBT (p = 0.011 and p < 0.001, respectively). Detrusor muscle was present in 58.6% of cases treated with conventionalTURBT vs 91.6% for the Tm-fiber ERBT group (p < 0.001). The obturator nerve reflex and bleeding were noted in 17.2% and 10.3% of TURBT cases, respectively; and in none of cases treated with Tm-fiber ERBT. Limitations included the non–randomized nature and the small sample size.CONCLUSIONS:Tm-fiber ERBT seems to be a safe and efficacious treatment option for NMIBC. Tm-fiber ERBT had fewer adverse events, was more likely to secure detrusor muscle in the specimen and resulted in better RFS rates than conventional TURBT. Based on these promising data, we have started a prospective randomized clinical trial comparing en bloc TURBT with conventional TURBT (ClinicalTrials.gov NCT03718754).
- Добавил в систему: Сорокин Николай Иванович