New functional criterion for evaluation of homologous MDR pumps

Авторы: Nazarov P.A., Sorochkina A.I., Karakozova M.V.
Журнал: Frontiers in microbiology
Год издания: 2020
Издательство: Frontiers Research Foundation
Местоположение издательства: Switzerland
DOI: 10.3389/fmicb.2020.592283
Аннотация: In recent years, bacterial resistance has become increasingly important for health care. With a simultaneous decrease in the number of newly registered antibacterial drugs, resistance to them is growing at an ever-higher rate, which makes the development of new drugs an expensive and ineffective undertaking. Therefore, creation of effective new antibacterial drugs is the most important task of modern Drug Development. Recently, several antibacterial drugs have been discovered [1-6]; however, for all of them, there are restrictions on the spectrum of action on bacteria. Some of them are active only towards gram-negative bacteria [3, 4], while others towards gram-positive [2]. However, for one of them [5, 6], the spectrum of action opened up as the antibiotic was being studied, from acting only towards gram-positive bacteria [5], to acting on any bacteria, with the exception of those which had a certain AcrAB-TolC multidrug resistance pump [6, 7].
Добавил в систему: Назаров Павел Александрович

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