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Hybrid Tricalcium Phosphate/Hydrogel Constructs Functionalized with an Antitumor Drug for Bone Tissue Regenerationстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 29 апреля 2021 г.
- Авторы: Karalkin P.A., Sergeyeva N.S., Sviridova I.K., Kirsanova V.A., Akhmedova S.A., Shansky Ya D., Leontyev N.V., Zuyev D.M., Klimashina E.S., Yevdokimov P.V., Putlyaev V.I.
- Журнал: Inorganic Materials: Applied Research
- Том: 11
- Номер: 5
- Год издания: 2020
- Первая страница: 1144
- Последняя страница: 1152
- DOI: 10.1134/s2075113320050160
- Аннотация: Hybrid materials designed for the regeneration of bone defects and consisting of a resorbableceramic base (tricalcium phosphate, TCP) coated with a layer of hydrophilic biodegradable polymer havebeen developed. Biocompatibility of the ceramics was evaluated through in vitro tests using cultures of humanskin fibroblasts. To increase the therapeutic potential, the created model structures were saturated with theantitumor drug doxorubicin within the composition of the coating of UV-polymerizable hydrogel based onpolyacrylamide/polyethylene glycol diacrylate (PAA/PEGDA). The kinetics of drug release was studied byspectrophotometry using saline. The studied hybrid constructs had low cytotoxicity. Saturation of the structureswith the antitumor drug resulted in its prolonged release. The results demonstrate the technological feasibilityof creating osteoconductive implants based on calcium phosphates suitable for local delivery of antitumordrugs.
- Добавил в систему: Путляев Валерий Иванович
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | IMAR1144.pdf | IMAR1144.pdf | 1,3 МБ | 22 октября 2020 [putl] |