The Problem of Apoptotic Processes Reversibility

Zakharov, I.I.; Savitskaya, M.A.; Onishchenko, G.E.

Авторы: Zakharov I.I., Savitskaya M.A., Onishchenko G.E.
Журнал: Biochemistry (Moscow)
Том: 85
Номер: 10
Год издания: 2020
Издательство: Pleiades Publishing, Ltd
Местоположение издательства: Road Town, United Kingdom
Первая страница: 1145
Последняя страница: 1158
DOI: 10.1134/S000629792010003X
Аннотация: Apoptosis is the best understood variant of regulated cell death, which has been considered irreversible for a long time. To date, an increasing amount of data has been accumulating indicating that key events of apoptosis, such as the externalization of phosphatidylserine, mitochondrial outer membrane permeabilization, caspase activation, DNA damage, and cytoplasmic blebbing are not irreversible and can be involved in the normal cell functioning not associated with the induction of apoptosis. Anastasis – cell recovery after induction of apoptosis – can occur following elimination of proapoptotic stimuli. This can facilitate survival of damaged or tumor cells. This review describes key processes of apoptosis, which donot necessarily lead to cell death during normal cell activity as well as anastasis. Understanding mechanisms and consequences of apoptotic processes reversibility, on the one hand, could contribute to the improvement of existing therapeutic approaches for various diseases, including malignant neoplasms, and, on the other hand, could open up new possibilities for protecting cellular elements of tissues and organs from death during treatment of degenerative pathologies.
Добавил в систему: Захаров Илья Игоревич

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