Enzyme-polyelectrolyte complexes for detoxification of mycotoxins

Авторы: Efremenko E.N., Lyagin I.V., Aslanli A.G.
Сборник: Vth International Conference “Actual Scientific & Technical Issues of Chemical Safety” (ASTICS-2020) Kazan, October 6 - 8, 2020. Book of Abstracts eds.: Prof. Alexander V. Roshchin, PhD Elena G. Raevskaya
Тезисы
Год издания: 2020
Место издания: Казань
Первая страница: 223
Последняя страница: 224
DOI: 10.25514/CHS.2020.05.7755
Аннотация: The aim of this work was to develop stabilized forms of combinedenzyme preparations by forming similar non-covalent enzyme-polyelectrolytecomplexes (EPCs) for their subsequent use in the degradation processes ofseveral mycotoxins aimed at disinfection of raw materials and products.To develop these stable forms of enzymes, we used the same approach as previously was applied for the hexahistidine-tagged organophosphorus hydrolase (His6-OPH) degrading organophosphorus pesticides [3–6]. To start with, the Lomonosov supercomputer (developed at Lomonosov Moscow StateUniversity) [7] was applied to calculate possible modes of interaction of a number of polyelectrolytes with selected enzymes that could modify various mycotoxins, namely: Zn-dependent neutral protease (1npc), resorcylate decarboxylase (2dvx), aflatoxin oxidase (AFO) (5yfd), and carboxypeptidase A (1yme).
Добавил в систему: Маслова Ольга Васильевна

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