Impairment of context memory by beta-amyloid peptide in terrestrial snail

Korshunova, T.A.; Bravarenko, N.I.; Balaban, P.M.

Авторы: Korshunova Tatiana A., Bravarenko Natalia I., Balaban Pavel M.
Журнал: Frontiers in Behavioral Neuroscience
Том: 2
Год издания: 2008
Издательство: Frontiers Research Foundation
Местоположение издательства: Switzerland
DOI: 10.3389/neuro.08/003.2008
Аннотация: We examined influence of the beta-amyloid peptide (betaAP) (25-35) neurotoxic fragment on Helix lucorum food-aversion learning. Testing with aversively conditioned carrot showed that 2, 5 and 14 days after training the betaAP-injected group responded in a significantly larger number of cases and with a significantly smaller latency than the sham-injected control group. The results demonstrate that the AP partially impairs the learning process. In an attempt to specify what component of memory is impaired we compared responses in a context in which the snails were aversively trained, and in a neutral context. It was found that the sham-injected learned snails significantly less frequently took the aversively conditioned food in the context in which the snails were shocked, while the betaAP-injected snails remembered the aversive context 2 days after associative training, but were not able to distinguish two contexts 5, and 14 days after training. In a separate series of experiments a specific context was associated with electric shock, and changes in general responsiveness were tested in two contexts several days later. It was found that the betaAP-injected snails significantly increased withdrawal responses in all tested contexts, while the sham-injected control animals selectively increased responsiveness only in the context in which they were reinforced with electric shocks. These results demonstrate that the betaAP (25-35) interferes with the learning process, and may play a significant role in behavioral plasticity and memory by selectively impairing only one component of memory - the context memory.
Добавил в систему: Балабан Павел Милославович

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Impairment of context memory by beta-amyloid peptide in terrestrial snailстатья