Nonphosphorylating Oxidation in Mitochondria and Related Processes

Zorov, D.B.; Andrianova, N.V.; Babenko, V.A.; Bakeeva, L.E.; Zorov, S.D.; Zorova, L.D.; Pevsner, I.B.; Popkov, V.A.; Plotnikov, E.Y.; Silachev, D.N.

Авторы: Zorov D.B., Andrianova N.V., Babenko V.A., Bakeeva L.E., Zorov S.D., Zorova L.D., Pevsner I.B., Popkov V.A., Plotnikov E.Yu, Silachev D.N.
Журнал: Biochemistry (Moscow)
Том: 85
Номер: 12
Год издания: 2020
Издательство: Pleiades Publishing, Ltd
Местоположение издательства: Road Town, United Kingdom
DOI: 10.1134/S0006297920120093
Аннотация: The mechanism of oxidative phosphorylation and its regulation remain one of the main problems of bioenergetics. The efficiency of mitochondrial energization is determined by the relationship between the rate of generation of the electrochemical potential of hydrogen ions and the rate of its expenditure on the synthesis of ATP and the use of ATP in endergonic reactions. Uncoupling (partial or complete), which occurs in the process of uncontrolled and controlled leakage of ions through the inner mitochondrial membrane, on the one hand leads to a decrease in the relative synthesis of ATP, and on the other, being consistent with the law of conservation of energy, leads to the formation of heat, the generation of which is an essential function of the organism. In addition to increased thermogenesis, an increase in non-phosphorylating oxidation of various substrates is accompanied by a decrease in the transmembrane potential and production of reactive oxygen species and activation of oxygen consumption, water and carbon dioxide production, an increase in the level of intracellular ADP and acidification of the cytosol. In this analysis, each of these factors will be considered separately for its role in regulating metabolism.
Добавил в систему: Андрианова Надежда Владимировна

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